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Developing a new type of cancer microenvironment enhancer
Developing a new type of cancer microenvironment enhancer is now being considered as one of the most important process to improve the success of current cancer therapy including immunotherapy. As cancer micrenvironment is a complicated network consisted of numbers of components, enhancers could be vary depending on the targets. In this lab, immunosuppressive factors such as hypoxia, immunosuppressive cytokines, immunosuppressive cells and etc. are the main interests to target. Espeacially, orally available agents are preferable as the drug concentration must be maintained in the blood to continusouly affect the tumor microenvrionemnt. In that aspect, developing a new macromolecular deliverying technique is also one of our great interests.
Nanotechnique based oral cancer vaccine
Developing new type of oral cancer nano-vaccine is one of our interests. As the mesenteric lymph node can be one of the most effective target for vaccine, we are trying to develop mesenteric lymph node targeting cancer nano-vaccine using novel surface modification technique to boost systemic immunity. On the first step, we are planning to consititue a library of orally available nano-carrier, which can deliver cancer specific antigen and adjuvant to mesenteric lymph node. Seconly, the delivery of antigens to mesenteric lymph node and activation of systemic immunity will be demonstrated. Finally, anti-cancer efficacy of the vaccine will be evaluated and the mechanism of work of vaccine will be validated.
Cell based cancer immune-patch system
A new type of cell based immune-patch system is also one of our great interests. A new technique for preparing macrophage based 3 demensional spheroid system served as 'cytokine depod' will be applied to modulate tumor microenvironment. Together with macrophage spheroid, tumor specific T-cells such as CAR-T cells will be loaded on to biocompatible scaffold simaltaneously to effectively treat the cancers.
Biomimetic multi-functional anti-cancer therapeutics
Nanoparticle based biomimetic anti-cancer therapeutics mimics cancer cells by covering cancer membrane onto the nanoparticle. Before covering the cancer membrane, we engineered the membrane to activate both innate and adaptive immunity effectively by inducing immunogenic cell death, applying alpha-galactosylceramide, attaching CD47 antibody and inducing IFN-r expression. This biomimetic cancer membrane covered nanoparticle are expected to effectively activate dendritic cells and iNKT cells to kill and take up the cancer cells followed by T-cell activation.
Call
+82-02-961-0693
Location
Room B123, Department of Regulatory Sciences, College of Pharmacy, 26 Kyunghee-daero, Dongdaemun-gu, Seoul, 02447, Republic of Korea